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Dr Sarah Ashley

Dr Sarah Ashley

Details

Role Senior Research Officer
Since 2013, my research program has been to understand the origins and immune mechanisms of food allergy. During my PhD candidature I explored the genetic architecture of food allergy, aiming to understand why some individuals are more predisposed than others. My research program added new knowledge to a field which had been poorly understood due to the challenges of safely and robustly diagnosing reactive allergy. After my PhD I started to investigate mechanisms of treatments for food allergy. In Berlin I diversified my skill set, and developed my bioinformatics skills, examining the transcriptomic and epigenomic changes occurring in response to peanut oral immunotherapy (OIT) to treat peanut allergies. My research program has expanded to a more holistic approach to identify the immunological remodeling occurring during OIT, covering single-cell RNAseq on immune cells, spectral cytometry for immune cell phenotyping, serological and cytokine studies. With this systems biology approach I aim to identify key biomarkers of allergy remission, so that given a snapshot of a patient’s immune profile during treatment, we could accurately predict whether treatment can be safely discontinued. Ultimately generating a more personalized medicine approach to provide the best outcomes during treatment. Since joining the Allergy Immunology research group, Murdoch Children’s Research Institute in mid-2019, I have continued to build my research network and form new collaborations, particularly in genomics and bioinformatics. I am a member of the Advisory Committee for the Food Allergy stream of the newly established National Allergy Centre of Excellence (NACE) and an NHMRC Centre for Research Excellence CFAR3 (Centre for Food and Allergy Research) funded postdoc.
Since 2013, my research program has been to understand the origins and immune mechanisms of food allergy. During my PhD candidature I explored the genetic architecture of food allergy, aiming to understand why some individuals are more predisposed...
Since 2013, my research program has been to understand the origins and immune mechanisms of food allergy. During my PhD candidature I explored the genetic architecture of food allergy, aiming to understand why some individuals are more predisposed than others. My research program added new knowledge to a field which had been poorly understood due to the challenges of safely and robustly diagnosing reactive allergy. After my PhD I started to investigate mechanisms of treatments for food allergy. In Berlin I diversified my skill set, and developed my bioinformatics skills, examining the transcriptomic and epigenomic changes occurring in response to peanut oral immunotherapy (OIT) to treat peanut allergies. My research program has expanded to a more holistic approach to identify the immunological remodeling occurring during OIT, covering single-cell RNAseq on immune cells, spectral cytometry for immune cell phenotyping, serological and cytokine studies. With this systems biology approach I aim to identify key biomarkers of allergy remission, so that given a snapshot of a patient’s immune profile during treatment, we could accurately predict whether treatment can be safely discontinued. Ultimately generating a more personalized medicine approach to provide the best outcomes during treatment. Since joining the Allergy Immunology research group, Murdoch Children’s Research Institute in mid-2019, I have continued to build my research network and form new collaborations, particularly in genomics and bioinformatics. I am a member of the Advisory Committee for the Food Allergy stream of the newly established National Allergy Centre of Excellence (NACE) and an NHMRC Centre for Research Excellence CFAR3 (Centre for Food and Allergy Research) funded postdoc.

Top Publications

  • Anderson, J, Imran, S, Ng, YY, Wang, T, Ashley, S, Minh Thang, C, Quang Thanh, L, Thi Trang Dai, V, Van Thanh, P, Thi Hong Nhu, B, et al. Differential anti-viral response to respiratory syncytial virus A in preterm and term infants.. EBioMedicine 102: 105044 2024
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  • Ashley, SE, Bosco, A, Tang, MLK. Transcriptomic changes associated with oral immunotherapy for food allergy. Pediatric Allergy and Immunology 35(3) : 2024
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  • Loke, P, Hsiao, K-C, Lozinsky, A, Ashley, S, Lloyd, M, Pitkin, S, Axelrad, C, Jayawardana, K, Tey, D, Su, E-L, et al. Probiotic and Peanut OIT leads to long-lasting sustained unresponsiveness and quality-of-life improvement in peanut-allergic children. 2024
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  • Ashley, S, Bosco, A, Tang, M. Transcriptomic changes associated with oral immunotherapy for food allergy. 2024
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  • Lloyd, M, Loke, P, Ashley, S, Lozinsky, AC, Orsini, F, O'Sullivan, M, Gold, M, Quinn, P, Metcalfe, J, Tang, MLK. Interaction Between Baseline Participant Factors and Treatment Effects Following Peanut Oral Immunotherapy.. J Allergy Clin Immunol Pract 2023
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Career information