Dr Elizabeth Ng
Dr Elizabeth Ng
Details
Role
Group Leader / Principal Research Fellow
Research area
Stem Cell Medicine
Group
Blood Development
Contact
Available for student supervision
Dr Elizabeth Ng is a Team Leader in the Blood Development Laboratory at the Murdoch Children's Research Institute (MCRI). After completing her undergraduate degree at the University of Melbourne, she received her PhD from Monash University in 2013. A major focus of her work is to generate transplantable haematopoietic stem cells (HSCs) from human pluripotent stem cells for tissue repair and regeneration, disease modeling and the testing of pharmaceuticals and other therapeutic products. Dr Ng has devised and patented protocols for haematopoietic differentiation together with a differentiation medium that supports the efficient production of large numbers of blood cells. APEL medium has been licensed and commercialised by STEMCELL Technologies. She has maintained a long-standing collaboration with Professor Andrew Elefanty (Blood Development) and Professor Ed Stanley (Immune Development), together making important contributions to the development of human pluripotent stem cell as a powerful experimental platform to drive advancement in differentiation systems, cell culture medium formulation and the use of genetic modifications of human pluripotent stem cell lines.
Her work has identified that the expression of the HOXA genes during differentiation is crucial for generating haematopoietic cells with a transcriptional profile similar to the 'preHSCs' seen in the aorta-gonad mesonephros (AGM) region of the human embryo. Her current work focuses upon the challenge of maturing these cells further to produce engraftable HSCs and to develop in vitro 'niches' that mimic the bone marrow in order to sustain them. Her work is supported by grants from the NHMRC, a research collaboration with CSL Ltd and she is currently a Principal Investigator of the Novo Nordisk Foundation Center for Stem Cell Medicine.
Dr Ng holds active collaborations with:
• Prof Andrew Elefanty, Blood Development Laboratory, Murdoch Children's Research Institute
• Prof Ed Stanley, Immune Development Laboratory, Murdoch Children's Research Institute
• Prof Constanze Bonifer, Institute of Cancer and Genomic Sciences, University of Birmingham
• Prof Hanna Mikkola, Department of Molecular, Cell and Developmental Biology University of California
Her work has identified that the expression of the HOXA genes during differentiation is crucial for generating haematopoietic cells with a transcriptional profile similar to the 'preHSCs' seen in the aorta-gonad mesonephros (AGM) region of the human embryo. Her current work focuses upon the challenge of maturing these cells further to produce engraftable HSCs and to develop in vitro 'niches' that mimic the bone marrow in order to sustain them. Her work is supported by grants from the NHMRC, a research collaboration with CSL Ltd and she is currently a Principal Investigator of the Novo Nordisk Foundation Center for Stem Cell Medicine.
Dr Ng holds active collaborations with:
• Prof Andrew Elefanty, Blood Development Laboratory, Murdoch Children's Research Institute
• Prof Ed Stanley, Immune Development Laboratory, Murdoch Children's Research Institute
• Prof Constanze Bonifer, Institute of Cancer and Genomic Sciences, University of Birmingham
• Prof Hanna Mikkola, Department of Molecular, Cell and Developmental Biology University of California
Dr Elizabeth Ng is a Team Leader in the Blood Development Laboratory at the Murdoch Children's Research Institute (MCRI). After completing her undergraduate degree at the University of Melbourne, she received her PhD from Monash University in 2013. A...
Dr Elizabeth Ng is a Team Leader in the Blood Development Laboratory at the Murdoch Children's Research Institute (MCRI). After completing her undergraduate degree at the University of Melbourne, she received her PhD from Monash University in 2013. A major focus of her work is to generate transplantable haematopoietic stem cells (HSCs) from human pluripotent stem cells for tissue repair and regeneration, disease modeling and the testing of pharmaceuticals and other therapeutic products. Dr Ng has devised and patented protocols for haematopoietic differentiation together with a differentiation medium that supports the efficient production of large numbers of blood cells. APEL medium has been licensed and commercialised by STEMCELL Technologies. She has maintained a long-standing collaboration with Professor Andrew Elefanty (Blood Development) and Professor Ed Stanley (Immune Development), together making important contributions to the development of human pluripotent stem cell as a powerful experimental platform to drive advancement in differentiation systems, cell culture medium formulation and the use of genetic modifications of human pluripotent stem cell lines.
Her work has identified that the expression of the HOXA genes during differentiation is crucial for generating haematopoietic cells with a transcriptional profile similar to the 'preHSCs' seen in the aorta-gonad mesonephros (AGM) region of the human embryo. Her current work focuses upon the challenge of maturing these cells further to produce engraftable HSCs and to develop in vitro 'niches' that mimic the bone marrow in order to sustain them. Her work is supported by grants from the NHMRC, a research collaboration with CSL Ltd and she is currently a Principal Investigator of the Novo Nordisk Foundation Center for Stem Cell Medicine.
Dr Ng holds active collaborations with:
• Prof Andrew Elefanty, Blood Development Laboratory, Murdoch Children's Research Institute
• Prof Ed Stanley, Immune Development Laboratory, Murdoch Children's Research Institute
• Prof Constanze Bonifer, Institute of Cancer and Genomic Sciences, University of Birmingham
• Prof Hanna Mikkola, Department of Molecular, Cell and Developmental Biology University of California
Her work has identified that the expression of the HOXA genes during differentiation is crucial for generating haematopoietic cells with a transcriptional profile similar to the 'preHSCs' seen in the aorta-gonad mesonephros (AGM) region of the human embryo. Her current work focuses upon the challenge of maturing these cells further to produce engraftable HSCs and to develop in vitro 'niches' that mimic the bone marrow in order to sustain them. Her work is supported by grants from the NHMRC, a research collaboration with CSL Ltd and she is currently a Principal Investigator of the Novo Nordisk Foundation Center for Stem Cell Medicine.
Dr Ng holds active collaborations with:
• Prof Andrew Elefanty, Blood Development Laboratory, Murdoch Children's Research Institute
• Prof Ed Stanley, Immune Development Laboratory, Murdoch Children's Research Institute
• Prof Constanze Bonifer, Institute of Cancer and Genomic Sciences, University of Birmingham
• Prof Hanna Mikkola, Department of Molecular, Cell and Developmental Biology University of California
Top Publications
- Ferreira, LGA, Cabral-da-Silva, MC, Pachernegg, S, van den Bergen, JA, Robevska, G, Vlahos, K, Howden, SE, Ng, ES, Dias-da-Silva, MR, Sinclair, AH, et al. Generation of heterozygous (MCRIi030-A-1) and homozygous (MCRIi030-A-2) NR2F2/COUP-TFII knockout human iPSC lines.. Stem Cell Res 76: 103374 2024 view publication
- Lamandé, SR, Ng, ES, Cameron, TL, Kung, LHW, Sampurno, L, Rowley, L, Lilianty, J, Patria, YN, Stenta, T, Hanssen, E, et al. Modeling human skeletal development using human pluripotent stem cells.. Proc Natl Acad Sci U S A 120(19) : e2211510120 2023 view publication
- Sun, S, Wijanarko, K, Liani, O, Strumila, K, Ng, ES, Elefanty, AG, Stanley, EG. Lymphoid cell development from fetal hematopoietic progenitors and human pluripotent stem cells.. Immunol Rev 315(1) : 154 -170 2023 view publication
- Saxena, R, Elefanty, A, Labonne, T, Ng, E, Stanley, E. 3170 – TRACKING DEVELOPMENT OF RUNX1+ HEMOGENIC ENDOTHELIUM IN VITRO. Experimental Hematology 124: s134 2023 view publication
- Sun, S, See, M, Nim, HT, Strumila, K, Ng, ES, Hidalgo, A, Ramialison, M, Sutton, P, Elefanty, AG, Sarkar, S, et al. Human pluripotent stem cell-derived macrophages host Mycobacterium abscessus infection.. Stem Cell Reports 17(9) : 2156 -2166 2022 view publication
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