Dr Cameron Osborne
Dr Cameron Osborne
Dr Cameron Osborne is a Senior Research Fellow in the Blood Diseases Laboratory at the Murdoch Children’s Research Institute. His research focuses on how genome organisation and nuclear structure influence genetic programs in development and disease. He has contributed experimental and computational methodological advances in mapping global long-range gene regulatory interactions.
After completing an undergraduate degree at Simon Fraser University, Vancouver, Canada, he obtained a PhD degree at Adelaide University, for his characterisation of gene regulatory elements, in the laboratory of Peter Cockerill. In his postdoctoral research in the laboratory of James Ellis at the Hospital for Sick Children, Toronto, Canada, he was awarded a fellowship by the Thalassemia Foundation of Canada to develop retroviral gene therapy vectors for the treatment of haemoglobinopathies. He then joined Peter Fraser’s group at the Babraham Institute, Cambridge, UK, where he researched beta-globin gene regulation and the nuclear organisation of transcription. He was awarded a Bennett Senior Fellowship (Blood Cancer UK) to set up a research group to study long-range gene regulation in leukaemia, which he continued after moving to King’s College London. He joined the Murdoch Children’s Research Institute in 2023.
After completing an undergraduate degree at Simon Fraser University, Vancouver, Canada, he obtained a PhD degree at Adelaide University, for his characterisation of gene regulatory elements, in the laboratory of Peter Cockerill. In his postdoctoral research in the laboratory of James Ellis at the Hospital for Sick Children, Toronto, Canada, he was awarded a fellowship by the Thalassemia Foundation of Canada to develop retroviral gene therapy vectors for the treatment of haemoglobinopathies. He then joined Peter Fraser’s group at the Babraham Institute, Cambridge, UK, where he researched beta-globin gene regulation and the nuclear organisation of transcription. He was awarded a Bennett Senior Fellowship (Blood Cancer UK) to set up a research group to study long-range gene regulation in leukaemia, which he continued after moving to King’s College London. He joined the Murdoch Children’s Research Institute in 2023.
Dr Cameron Osborne is a Senior Research Fellow in the Blood Diseases Laboratory at the Murdoch Children’s Research Institute. His research focuses on how genome organisation and nuclear structure influence genetic programs in development and...
Dr Cameron Osborne is a Senior Research Fellow in the Blood Diseases Laboratory at the Murdoch Children’s Research Institute. His research focuses on how genome organisation and nuclear structure influence genetic programs in development and disease. He has contributed experimental and computational methodological advances in mapping global long-range gene regulatory interactions.
After completing an undergraduate degree at Simon Fraser University, Vancouver, Canada, he obtained a PhD degree at Adelaide University, for his characterisation of gene regulatory elements, in the laboratory of Peter Cockerill. In his postdoctoral research in the laboratory of James Ellis at the Hospital for Sick Children, Toronto, Canada, he was awarded a fellowship by the Thalassemia Foundation of Canada to develop retroviral gene therapy vectors for the treatment of haemoglobinopathies. He then joined Peter Fraser’s group at the Babraham Institute, Cambridge, UK, where he researched beta-globin gene regulation and the nuclear organisation of transcription. He was awarded a Bennett Senior Fellowship (Blood Cancer UK) to set up a research group to study long-range gene regulation in leukaemia, which he continued after moving to King’s College London. He joined the Murdoch Children’s Research Institute in 2023.
After completing an undergraduate degree at Simon Fraser University, Vancouver, Canada, he obtained a PhD degree at Adelaide University, for his characterisation of gene regulatory elements, in the laboratory of Peter Cockerill. In his postdoctoral research in the laboratory of James Ellis at the Hospital for Sick Children, Toronto, Canada, he was awarded a fellowship by the Thalassemia Foundation of Canada to develop retroviral gene therapy vectors for the treatment of haemoglobinopathies. He then joined Peter Fraser’s group at the Babraham Institute, Cambridge, UK, where he researched beta-globin gene regulation and the nuclear organisation of transcription. He was awarded a Bennett Senior Fellowship (Blood Cancer UK) to set up a research group to study long-range gene regulation in leukaemia, which he continued after moving to King’s College London. He joined the Murdoch Children’s Research Institute in 2023.
Top Publications
- Villiers, W, Kelly, A, He, X, Kaufman-Cook, J, Elbasir, A, Bensmail, H, Lavender, P, Dillon, R, Mifsud, B, Osborne, CS. Multi-omics and machine learning reveal context-specific gene regulatory activities of PML::RARA in acute promyelocytic leukemia.. Nat Commun 14(1) : 724 2023 view publication
- Osborne, CS, Mifsud, B. Capturing genomic relationships that matter.. Chromosome Res 25(1) : 15 -24 2017 view publication
- Aljogol, D, Thompson, IR, Osborne, CS, Mifsud, B. Comparison of Capture Hi-C Analytical Pipelines.. Front Genet 13: 786501 2022 view publication
- Yun, H, Narayan, N, Vohra, S, Giotopoulos, G, Mupo, A, Madrigal, P, Sasca, D, Lara-Astiaso, D, Horton, SJ, Agrawal-Singh, S, et al. Mutational synergy during leukemia induction remodels chromatin accessibility, histone modifications and three-dimensional DNA topology to alter gene expression.. Nat Genet 53(10) : 1443 -1455 2021 view publication
- Sasca, D, Yun, H, Giotopoulos, G, Szybinski, J, Evan, T, Wilson, NK, Gerstung, M, Gallipoli, P, Green, AR, Hills, R, et al. Cohesin-dependent regulation of gene expression during differentiation is lost in cohesin-mutated myeloid malignancies.. Blood 134(24) : 2195 -2208 2019 view publication
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