A/Prof Shireen Lamande
A/Prof Shireen Lamande
Details
Role
Princ Res Fellow, Lead, Bone & Cartilage
Research area
Stem Cell Medicine
Group
Blood Development
Human skeletal development and correct bone, cartilage, joint and muscle function are determined by complex interactions between developmental signalling pathways. Genetic and acquired disorders affecting these tissues are common. The group’s research aims to understand the molecular basis of these disorders to improve diagnosis and genetic counselling, identify new therapeutic targets and test new treatments to ultimately improve the quality of life for children with these debilitating conditions
Human skeletal development and correct bone, cartilage, joint and muscle function are determined by complex interactions between developmental signalling pathways. Genetic and acquired disorders affecting these tissues are common. The group’s...
Human skeletal development and correct bone, cartilage, joint and muscle function are determined by complex interactions between developmental signalling pathways. Genetic and acquired disorders affecting these tissues are common. The group’s research aims to understand the molecular basis of these disorders to improve diagnosis and genetic counselling, identify new therapeutic targets and test new treatments to ultimately improve the quality of life for children with these debilitating conditions
Top Publications
- Lamandé, SR, Ng, ES, Cameron, TL, Kung, LHW, Sampurno, L, Rowley, L, Lilianty, J, Patria, YN, Stenta, T, Hanssen, E, et al. Modeling human skeletal development using human pluripotent stem cells. Proceedings of the National Academy of Sciences of the United States of America 120(19) : e2211510120 2023 view publication
- Yeung, C-YC, Olesen, AT, Wilson, R, Lamandé, SR, Bateman, JF, Svensson, RB, Magnusson, SP, Kjaer, M. Proteome profiles of intramuscular connective tissue: influence of aging and physical training. Journal of Applied Physiology 134(5) : 1278 -1286 2023 view publication
- Yammine, KM, Mirda Abularach, S, Sampurno, L, Bateman, JF, Lamandé, SR, Shoulders, MD. Using CRISPR/Cas9 to generate a heterozygous COL2A1 p.R719C iPSC line (MCRIi019-A-6) model of human precocious osteoarthritis. Stem Cell Research 67: 103020 2023 view publication
- Blank, M, McGregor, NE, Rowley, L, Kung, LHW, Crimeen-Irwin, B, Poulton, IJ, Walker, EC, Gooi, JH, Lamandé, SR, Sims, NA, et al. The effect of carbamazepine on bone structure and strength in control and osteogenesis imperfecta (Col1a2 +/p.G610C ) mice.. J Cell Mol Med 26(14) : 4021 -4031 2022 view publication
- Bateman, JF, Shoulders, MD, Lamandé, SR. Collagen misfolding mutations: the contribution of the unfolded protein response to the molecular pathology. Connective Tissue Research 63(3) : 210 -227 2022 view publication
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